Phospholipidosis toxicity
WebThe HCS LipidTOX™ Red phospholipidosis detection reagent was developed to characterize the potentially toxic side effects of compounds on lipid metabolism in mammalian cell lines. This reagent is easily detected by fluorescence microscopy or an HCS reader equipped with filters that can detect excitation/emission maxima ∼595/615 nm. Webtoxicity Transcriptional profiling for the prioritization of compounds The integration of multiple testing platforms generates large data sets during early drug discovery is a common approach within the pharma- and can require the use of high-performance computing and machine- ceutical industry: 42% in our survey considered this a game …
Phospholipidosis toxicity
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WebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. [1] [2] [3] Certain cases may be triggered by medications. [4] … WebAug 16, 2004 · FDA Phospholipidosis Guidance Being Developed; Toxicity Is Concern 16 Aug 2004 News The Pink Sheet [email protected] Executive Summary FDA is planning to develop a guidance on phospholipidosis issues in drug products You may also be interested in... Sepracor Soltara “not approvable”
WebMar 5, 2015 · The fact that 97 displayed low toxicity toward common lab cell lines (HEK 293 and HeLa) suggests that this compound could also be a starting point for developing SIRT2 inhibitors able to target ... WebTraductions en contexte de "contrôlé chez le rat" en français-anglais avec Reverso Context : Suite à un choc hémorragique retransfusé et contrôlé chez le rat, le NaHS, donneur d'hydrogène sulfuré (H2S) limite la diminution de la pression artérielle moyenne après la …
WebApr 5, 2013 · The toxicity is difficult to recognize clinically due to its potential to mimic various conditions, but a biopsy is sometimes able to suggest the diagnosis. On morphology, regardless of the organ site, there appears to be a consistent presence of vacuolated cells and occasionally foamy macrophages and granulomas. WebOct 9, 2006 · Phospholipidosis – a defence mechanism of the cell?The biological consequence of phospholipid accumulations in several organs has not been evaluated to …
WebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues, often stimulated by drugs. Drug induced hepatotoxicity is a leading cause of attrition during drug development.
WebDec 14, 2009 · Phospholipidosis often occurs in the absence of any evidence of concurrent general or target organ toxicity or organ dysfunction. In drug development, PL alone is … eye chart jokeWebAug 16, 2004 · FDA also raised issues related to phospholipidosis and cardiomyopathy observed in animal safety studies. The Soltara NDA was submitted March 9, 2001. Soltara … herman hadi basukiWebDrug toxicity, often manifested as liver toxicity and cardiotoxicity, is a key reason for drug attrition. Identifying potential toxicity at an early stage in drug discovery can save both time and developmental costs, and most importantly reduce the likelihood of late stage failure. ... drug-induced phospholipidosis and steatosis, lysosomal ... herman grahamWebJun 6, 2016 · Phospholipidosis was characterized by a decreased lysophospholipids to phospholipids ratio, suggestive of phospholipid degradation inhibition. Whereas, steatosis led to impaired fatty acids... eyecon korfbalWebFeb 1, 2007 · Considering the binding component of the IAM retention mechanism, a high affinity to IAM stationary phases in the case of basic amphiphilic drugs may be … herman hannanWebJun 22, 2024 · Phospholipidosis depends on the physicochemical properties of drugs and does not reflect specific target-based activities—rather, it may be considered a toxic confound in early drug discovery. Early detection of phospholipidosis could eliminate … herman habermannWebOct 9, 2006 · Organs affected by phospholipidosis exhibit inflammatory reactions and histopathological changes. Despite significant advances in the understanding of drug … herman gundert malayalam