Phenprocoumon is used for the prophylaxis and treatment of thromboembolic disorders after heart bypass surgery and myocardial infarction (heart attack), long-term treatment of myocardial infarction with increased risk of thromboembolism, thrombophilia (abnormal blood clotting), antithrombin III … See more Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting blood thinner drug to be taken by mouth, and a derivative of coumarin. It acts as a vitamin K antagonist and … See more Phenprocoumon is contraindicated when bleeding risks exceed the potential benefits, for example in people with severe bleeding diathesis See more Mild cases of overdosing are characterised by minor bleeding and/or bruising; they can usually be controlled by reducing the dose. Taking a large amount of phenprocoumon at once can lead to brain edema during the first 24 hours, followed by reduced … See more Mechanism of action Phenprocoumon is an inhibitor of the enzyme vitamin K epoxide reductase (VKOR). Vitamin K is needed to activate the coagulation … See more The most common adverse effect is bleeding. It occurs in 5–25% of patients and ranges from harmless nosebleeds to life-threatening … See more Due to its narrow therapeutic index, the fact that it can only be eliminated from the body after inactivation by the liver enzymes CYP2C9 and CYP3A4, and its high plasma protein binding … See more Phenprocoumon, a 4-hydroxycoumarin structurally similar to warfarin, is a white to off-white crystalline powder with a characteristic smell. It is practically insoluble in water, but soluble in chloroform, ethanol, methanol, and aqueous See more WebPhenprocoumon is the dominant anticoagulant in clinical use in several continental European countries. It used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation.
Phenprocoumon - Wikipedia
WebJan 20, 2024 · Wichtige, in der Humanmedizin therapeutisch eingesetzte, Cumarin-Derivate sind: Phenprocoumon mit einer langen Plasmahalbwertszeit (HWZ) von 140 Stunden Warfarin mit einer mittleren HWZ von 40 Stunden Acenocoumarol mit einer kurzen HWZ von 10 Stunden (nicht in Deutschland zugelassen) WebFeb 22, 2024 · Phenobarbital is a prescription medicine used to treat and prevent the symptoms of seizures, sedation, hypnotics, Insomina and Status Epilepticus. Phenobarbital may be used alone or with other medications. … hws magenprobleme
The relationship between maintenance dosages of three vitamin K ...
WebPhenprocoumon is stereoselectively metabolized by hepatic microsomal enzymes (cytochrome P-450) to inactive hydroxylated metabolites (predominant route) and by … Web1120 rows · Phenprocoumon is an anticoagulant drug used for the prevention of … WebJul 10, 2024 · Treatment with vitamin K antagonists (VKA) requires a high proportion of time in the therapeutic range (TTR) and a low international normalised ratio (INR) variability to … hws mail