High dose ara-c
Web16 de nov. de 2006 · Methods: The DHAC regimen consists of Dexamethasone at 15mg/m 2 /dose po every 6 hours × 10 doses, High-dose Ara-C at 3gr/m 2 (1.5gr/m 2 if >50 yrs old) iv over 3 hrs every 12 hrs for 4 doses and Carboplatin at 200mg/m 2 iv every 24 hrs for 2 doses. When utilized, ... WebAn understanding of the cellular pharmacology, cytokinetics and pharmacokinetics of ara-C in leukemic mice showed substantial schedule-dependency. Exposure to high doses for a short duration (C × t) resulted in a palliative therapeutic outcome. In marked contrast, exposure to lower doses for a protracted period (c × T) was curative.
High dose ara-c
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Web1 de jan. de 1988 · Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone (DHAP) WS Velasquez, WS Velasquez Department of Hematology, University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston 77030. Web1 de jun. de 2024 · High-dose Ara-C–treated conditions (≥1,000 nmol/L) were measured after one month of recovery (C). D, Scheme demonstrating that patient-derived AML cells (AML2928) treated with a case-dependent high dose of Ara-C (3 days × 500 nmol/L) and re-treated after recovery from nadir.
WebIn this study, we have evaluated the pharmacology and toxicity of high-dose ara-c by 72-hour continuous infusion. Plasma ara-c concentrations varied from 3.6 μM at the starting dose of 4 g/m2/72 hours to 22.6 μM at 18 g. Plasma clearance appeared to decrease progressively at doses > 10 g, ... Web11 de abr. de 2024 · The total duration of treatment with Venetoclax will be 6 days (day -11 to -6 before stem cell infusion). Patients with active disease at transplant will receive a 3 …
Web20 de nov. de 2024 · Alternatively, a higher dose of 3.0mg/kg daunorubicin and 75mg/kg Ara-C was used (high dose DA therapy). For some experiments, doxorubicin was … Web20 de jan. de 2024 · Since a high dose (2,000–3,000 mg/m 2 every 12 hours for 3 days or more) of Ara-C may increase the risk of induced toxicity or even early death, we did not …
WebAra-C (Cytarabine) chemotherapy side effects, how it's given, how it works, precautions and self care tips in treatment of leukemia ... More often associated with high-dose …
WebIn conclusion, high-dose Ara-C and BEAM with stem cell rescue in newly diagnosed MCL patients responsive to R-CHOP is a manageable treatment with respect to toxicity. This regimen leads to long-term, but probably not durable, remissions. U2 - 10.1111/j.1365-2141.2008.07498.x. DO - 10.1111/j.1365-2141.2008.07498.x. cottontail cornerWebCytosine Arabinoside. Cytosine arabinoside (Ara-C or cytarabine) is used for hematological malignancies, breast cancer, and occasionally is given intrathecally for leptomeningeal carcinomatosis. High-dose Ara-C causes a reversible cerebellar syndrome in 10% to 20% of patients. It usually starts a few days after treatment, peaks at 2 to 3 days ... magda ovadia californiaWeb12 de abr. de 2024 · Fludarabine is a commonly used conditioning agent but as 60% of the active metabolite 2-fluoro-ara-A (F-ARA-A) is cleared by the kidney, concerns for fludarabine-induced neurotoxicity are high [6 ... magda montielWebA multicentric prospective pilot study using three different schedules of high-dose Ara-C at dosage of 3 g/m2 every 12 hours during 3 h of infusion was undertaken by the Italian … magdaprime distribution incorporatedWeb15 de jul. de 1987 · Abstract. The toxicity of high dose cytosine arabinoside (Ara-C) in 23 leukemic children aged 1.5 years to 16 years 11 months was evaluated. The group … magda riutort schappertWebCYTARABINE (ARA-C) HIGH DOSE INDICATION Consolidation chemotherapy for AML in remission. Consider dose reduction to 1.5g/m2 for patient ≥60 years old and for patient … magda profetaWeb11 de abr. de 2024 · The total duration of treatment with Venetoclax will be 6 days (day -11 to -6 before stem cell infusion). Patients with active disease at transplant will receive a 3-day ramp-up prephase of Ara-C (100mg total dose infused in 1h) with daily increasing doses of Venetoclax to prevent TLS during conditioning. magda priser