WebThis protein was named “erythroferrone” (Erfe), as it functions as a link between production of red blood cells (erythrocytes) and the regulation of iron (which has a Latin … WebThe Township of Fawn Creek is located in Montgomery County, Kansas, United States. The place is catalogued as Civil by the U.S. Board on Geographic Names and its elevation …
Erythroferrone contributes to iron mobilization for embryo ...
WebJan 15, 2024 · The erythroferrone gene ( ERFE ), also termed CTRP15 , belongs to the C1q tumor necrosis factor-related protein (CTRP) family. Despite multiple reports about … WebApr 7, 2024 · In response to acute haemorrhage or erythropoietic stress erythroferrone (ERFE) is produced and released by bone marrow erythroid progenitor cells. redi ferizaj
Entry - *615099 - ERYTHROFERRONE; ERFE - OMIM
WebErythroferrone (ERFE) is the main erythroid regulator of hepcidin, the homeostatic hormone controlling plasma iron levels and total body iron. When the release of erythropoietin from the kidney stimulates the … Erythroferrone is a protein hormone encoded in humans by the ERFE gene. Erythroferrone is produced by erythroblasts, inhibits the production of hepcidin in the liver, and so increases the amount of iron available for hemoglobin synthesis. Skeletal muscle secreted ERFE has been shown to maintain systemic … See more It was identified in 2014 in mice where the transcript was found in bone marrow, encoded by the mouse Fam132b gene. The homologous gene in humans is FAM132B and the sequence is conserved in other species. … See more Erythroferrone in humans is transcribed as a precursor of 354 amino acids, with a signal peptide of 28 amino acids. The mouse gene encodes a 340 amino acid protein which is 71% identical. Homology is greater at the C-terminal where there is a See more Synthesis of erythroferrone is stimulated by erythropoietin binding to its receptor and activating the Jak2/Stat5 signaling pathway. See more Erythroferrone is a hormone that regulates iron metabolism through its actions on hepcidin. As shown in mice and humans, it is produced in erythroblasts, which proliferate when new red cells are synthesized, such as after hemorrhage when more iron is … See more The clinical significance in humans is becoming clear. From parallels in the mouse studies, there may be diseases where its function could be relevant. In a mouse model of See more WebIntroduction. Erythroferrone (ERFE) plays a central role in the release of stored iron during stress erythropoiesis, being an effective inhibitor of hepcidin synthesis by hepatocytes. 1 ERFE is a member of the tumor necrosis factor- α (TNF-α) family, encoded by ERFE (FAM132B) gene, and is synthesized by erythroblasts upon erythropoietin (EPO) … rediculos snake