Ctcf is a barrier for 2c-like reprogramming
WebMay 27, 2024 · Although not strictly totipotent, 2CLCs are considered totipotent-like cells and are therefore a powerful cellular model to study molecular features related to totipotency. 2CLCs emerge most... WebJan 20, 2024 · Induction of 2C or 4C-like cells has also been done with chemical inhibitors, which could promote totipotent cells in ESC culture. This method could also be the promotion of 2C cells in ESC...
Ctcf is a barrier for 2c-like reprogramming
Did you know?
WebAug 11, 2024 · Depletion of CTCF in ESC efficiently promotes spontaneous and asynchronous conversion to a 2C-like state and is reversible upon restoration of CTCF … WebDec 22, 2024 · Here, we show that CTCF is a barrier for 2C-like reprogramming. Indeed, forced conversion to a 2C-like state by DUX expression was associated with DNA …
WebInterestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identified within ESC cultures. They arise from (PDF) CTCF is a barrier for 2C-like reprogramming Raphael Pavani - Academia.edu WebMar 3, 2024 · In both Calu-3 (Fig. 1A) and 16HBE14o- (Suppl. Fig. S-IIIA) cells, the most significant motifs were those for CCCTC-Binding Factor (CTCF) (Bell, West and Felsenfeld, 1999) and BORIS/CCCTC-Binding Factor Like (CTCFL)(Loukinov, Pugacheva, Vatolin et al., 2002). Also enriched at sites of BRD8 occupancy in both Calu-3 and 16HBE14o- …
WebDec 22, 2024 · 1 1 CTCF is a Barrier for Totipotent-like Reprogramming 2 Teresa Olbrich1, Maria Vega-Sendino1, Desiree Tillo2, Wei Wu1, Nicholas Zolnerowich1, Andy D. 3 Tran3, Catherine N. Domingo1, Mariajose Franco1, Marta Markiewicz-Potoczny1, Gianluca 4 Pegoraro4, Peter C. FitzGerald5, Michael J. Kruhlak3, Eros Lazzerini-Denchi1, … WebFeb 1, 2024 · While CTCF is required for proper embryonic development in multiple species, the dependence on its role as an insulator protein remains unclear. Interestingly, recent findings show that CTCF acts as a barrier for reprogramming of mESC …
WebMar 7, 2024 · Perturbations that slow replication fork speed promote 2-cell-like cell emergence and improve somatic cell nuclear transfer reprogramming and formation of …
WebMany attempts have been made to induce high-quality embryonic stem cells such as pluripotent stem cells and totipotent stem cells, but challenges remain to be overcome such as appropriate methods and sources. Demethylation of the genome after go live backgroundWebAug 11, 2024 · Based on the observed CTCF-associated DNA damage in DOX-induced ESC Dux, we speculated that CTCF might represent a barrier for the reprogramming to a 2C-like state. This idea was... We would like to show you a description here but the site won’t allow us. healthcare scholarships 2023WebA similar activation occurs in mouse embryonic stem cells, giving rise to 2-cell-like cells (2CLCs). Though the molecular mechanism underlying this expanded 2CLC potency caused by Dux activation has been partially revealed, the regulation mechanisms controlling Dux expression remain elusive. go live announcement templateWebCTCF is a barrier for 2C-like reprogramming Nature Communications August 11, 2024 See publication Following Trypanosoma cruzi RPA … health care scholarships for womenWebAug 11, 2024 · However, the molecular determinants of 2C-like conversion have not been completely elucidated. Here, we show that the CCCTC-binding factor (CTCF) is a … healthcare scholarships canadaWebMar 7, 2024 · CTCF is a barrier for 2C-like reprogramming. 11 August 2024. Teresa Olbrich, Maria Vega-Sendino, … Sergio Ruiz. The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming. healthcare scholarships singaporeWebAug 22, 2024 · Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M et al (2024) CTCF is a barrier for 2C-like reprogramming. Nature Communications 12: 4856 Crossref CAS PubMed Web of Science® Google Scholar go live anywhere