Cisplatin koordinationszahl
WebApr 22, 2024 · This work shows a new mechanism of cisplatin resistance in cancer caused by a commonly amplified gene,” Lin said. “Importantly, we identified panobinostat, an HDAC inhibitor, as a potential therapeutic …
Cisplatin koordinationszahl
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WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral membrane of proximal tubules and mediates the transport of cisplatin from the blood to proximal tubule cells. Cisplatin (cis-Diammindichloridoplatin; DDP) ist ein Arzneistoff (Zytostatikum zur Hemmung des Zellwachstums bzw. der Zellteilung) und enthält ein komplexgebundenes Platinatom. Die Wirkung beruht auf einer Hemmung der DNA-Replikation durch Querverknüpfungen zweier benachbarter … See more Cisplatin wurde zuerst 1844 von Michele Peyrone synthetisiert, damals bekannt als Peyrones Chlorid. Es spielte eine Rolle bei der Entwicklung der Komplexchemie durch Alfred Werner. Die Entdeckung der zytostatischen … See more Wirkungsmechanismus Cisplatin wirkt ähnlich wie bifunktionelle Alkylantien durch Querverknüpfungen von DNA-Strängen. Der stark elektrophile Aqua-Cisplatin … See more • Markus Galanski, Bernhard K. Keppler: Tumorhemmende Metallverbindungen. In: Pharmazie in unserer Zeit 35(2), S. 118–122 (2006), See more Cisplatin stellt einen planaren Komplex dar, der am zentralen Platinatom zwei cis-ständige Chloridliganden und zwei Amminliganden … See more Monopräparate Cis-GRY (D), Platiblastin (CH), Platinol (CH), zahlreiche Generika (D, A, CH). See more
WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and … WebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), …
WebCisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other cancers. It is best to read this information with our general information about chemotherapy and the … WebMaterial Name: Cisplatin Solution for Injection - 0.5 and 1 mg/ml Revision date: 02-Jan-2007 Page 7 of 7 Version: 1.1 16. OTHER INFORMATION Reasons for Revision: …
Webof cisplatin with urine from healthy subjects, except that the proportions are different. The parent compound, cisplatin, is excreted in the urine and accounts for 13% to 17% of the …
Webappropriate concentration, while cisplatin (Ebewe Pharma, Unterach, Austria) was given undiluted. The administered volumes for cisplatin and cefepime ranged from 0.3 to 0.91 ml and from 0.3 to 0.35 ml, respectively. Experimental procedure Cisplatin was administered in 10, 14, 18, 22 and 26 mg/kg doses; the control group received saline. office de tourisme aubenas ardècheWebJun 16, 2008 · Concentration-dependent assays were carried out in DMEM containing cisplatin at concentrations up to 1,000 μmol/L. The fraction unbound Pt in DMEM, determined using equilibrium dialysis, was found to range between 10% and 26% at total cisplatin concentrations of 50 and 1,000 μmol/L, respectively. office de tourisme auch gersWebNational Center for Biotechnology Information my city your city shoe cityWebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity … Cisplatin: The first metal based anticancer drug office de tourisme athenesWebJun 23, 2024 · Cisplatin 1 mg/ml Sterile Concentrate Active Ingredient: cisplatin Company: Hospira UK Ltd See contact details ATC code: L01XA01 About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals Last updated on emc: 23 Jun 2024 … my city world apkWebCisplatin has shown activity against osteosarcoma, transitional cell carcinoma, squamous cell carcinoma (SCC), melanoma, mesothelioma, carcinomatosis and germinal cell tumours in the dog. In the cat, cisplatin cannot be utilized because of fulminant pulmonary oedema that occurs at standard doses. my city winter havenWebThe optimal cumulative dose and timing of cisplatin administration in various concurrent chemoradiotherapy protocols for nonmetastatic head and neck squamous cell carcinoma … office de tourisme banyuls