WebOct 21, 2016 · Thus many anticancer drugs are designed to target DNA, and cisplatin is one most effective DNA-damaging agents. Its mode of action is relatively simple: The … Webfrom publication: Metal-based drug-DNA interactions Coordination compounds that bind to DNA have been an active area of research since the discovery of cisplatin and the plati-num based drugs.

Where does cisplatin bind? EurekAlert!

WebThrough the aquation process, cisplatin becomes highly reactive and readily binds to a variety of biomolecules inside the cell (1). In its reactive form, cisplatin covalently binds to DNA... Cisplatin interferes with DNA replication, which kills the fastest proliferating cells, which in theory are cancerous. Following administration, one chloride ion is slowly displaced by water to give the aquo complex cis-[PtCl(NH3)2(H2O)] , in a process termed aquation. Dissociation of the chloride is favored inside the cell because the intracellular chloride concentration is only 3–20% of the approxi… calvin roberts insurance

Theoretical Study of Cisplatin Binding to Purine Bases: …

WebAug 5, 2014 · Many components of the cell, including lipids, proteins and both nuclear and mitochondrial DNA, are vulnerable to deleterious modifications caused by reactive oxygen species. If not repaired, oxidative DNA damage can lead to disease-causing mutations, such as in cancer. Base excision repair and nucleotide excision repair are the two DNA repair … WebMeselson and Stahl relied on equilibrium density gradient centrifugation to resolve the DNA containing 14N from the DNA containing 15N. They started off with DNA in media … WebThe alteration of tumorigenic pathways leading to cancer is a degenerative disease process typically involving inactivation of tumor suppressor proteins and hyperactivation of oncogenes. One such oncogenic protein product is the murine double-minute 2, or Mdm2. While, Mdm2 has been primarily associated as the negative regulator of the p53 tumor … calvin robertson minnesota