WebThe hCTM01-NAc-gamma calicheamicin DM amide conjugate, referred to as CMB-401, shows targeted killing of MUC1-expressing cells in vitro and produces pronounced dose-related antitumor effects over an 8-fold dose range against a MUC1-expressing, ovarian xenograft tumor, OvCar-3. The specificity of CMB-401 was confirmed by comparing its … WebThe calculated docking energy of calicheamicin gamma(1) (I) (-12.5 kcal mol(-1)) is close to the measured value of -9.7 kcal mol(-1) and the site specificity is in line with experimental observations. Calicheamicin is triggered in the minor groove in such a way that out of a cyclohexenone by Michael addition an E rather than a Z form of a ...
The reactivity of calicheamicin gamma(1)(I) in the minor
WebMay 27, 1988 · Calicheamicin gamma 1I is a recently discovered diyne-ene--containing antitumor antibiotic with considerable potency against murine tumors. In vitro, this drug interacts with double-helical DNA in the minor groove and causes site-specific double-stranded cleavage. It is proposed that the observed cleavage specificity is a result of a … WebApr 29, 2016 · Calicheamicin γ 1 I (Figure 1) is a prototype of the 10-membered enediyne family of antibiotics that contains a characteristic bicyclo[7.3.1]tridecadiynene core. 12–15 12. J. S. Thorson, E. L. Sievers, J. Ahlert, E. Shepard, R. E. Whitwam, K. C. Onwueme, and M. Ruppen, “ Understanding and exploiting nature's chemical arsenal: The past, present … dappere kat accare
Synthetic calicheamicin mimics with novel initiation ... - PubMed
WebBackground: Calicheamicin gamma 1I is a bacterial product that is a prominent member of the enediyne class of antitumor antibiotics, and has been extensively studied. Calicheamicin gamma 1I binds to DNA, causing double-stranded breaks, and cells exposed to it eventually become apoptotic. It can now be made synthetically, and highly … WebCalicheamicin gamma-1, $\mathrm{C}_{55} \mathrm{H}_{74} \mathrm{IN}_{3} \mathrm{O}_{21} \mathrm{S}_{4},$ is one of the most potent antibiotics known: one molecule kills one bacterial cell. Describe how you would (carefully!) prepare 25.00 $\mathrm{mL} .$ of an aqueous calicheamicin gamma-1 solution that could kill $1.0 \times 10^{8}$ … WebQuestion: PartA Calicheamicin gamma-1, CssH7AIN O21S4, is one of the most potent antibiotics known: One molecule kills one bacterial cel Describe how you would (carefully) prepare 25.00 mL of an aqueous … dapper.com